About InnoGI technologies
At InnoGI Technologies, we are revolutionizing oral drug and food product development with our SurroGUT™ platform, the most realistic model of the human GI tract, replicating its dynamic behavior with high fidelity. With over 25 years of biopharma experience, we offer innovative solutions to streamline development, accelerate approvals, and reduce risks.
SurroGUT™ integrates a physiomechanical twin of the gut, a membrane-based biological twin replicating the gut wall, and a digital twin for PBPK/PBBM modeling, providing precise insights into how substances behave within the human GI tract.
The SurroGUT™ platform
Computer controlled GI models: mimicking with high fidelity
the real human gut
Upper GI: Stomach + Small intestinal model (tiny-TIMsg)
The tiny-TIMsg, has a high degree of automation making it more convenient and offering a high predictive value for clinical data. It has been successfully evaluated for research applications in the pharmaceutical, food/nutrition and animal feed industries. It supports compound selection, such as different drug substance modifications (e.g., different salts, dosage forms, formulations and/or excipients). tiny-TIMsg has the following features:
- An advanced gastric compartment (agc) for the realistic simulation of gastric activity and morphology
- True-to-life flow rates of bile and pancreatic secretions
Large intestinal model (TIM-2)
TIM-2 is an advanced dynamic in vitro model of the large intestine that replicates proximal colon conditions. It facilitates the analysis of fermentation, microbiome modulation, and overall colon health. It can be used to study the release, dissolution and stability of a formulation and assess the prebiotic potential of (novel) food products by testing the effect on the human gut microbiome. TIM-2 has the following features:
- Inoculated with active intestinal microbiota under anaerobic conditions
- Ability to use microbiota for healthy individuals or patients and different age categories (infants, adults, elderly, disease states)
- Continuous removal of fermentation products and metabolites to maintain healthy gut microbiota
Services
We can facilitate studies showing how the complex physiological conditions of the GI tract
affect oral formulations and novel foods
- Drug release and dissolution
- Formulation comparison and bioequivalence
- Flexible physiological settings (healthy, pediatric, disease and animal models)
- PBPK/PBB modeling and IVIVC
- Drug permeability assays (coming soon)
- Food effect and drug-drug interactions
- Microbiome and bacterial survival studies
- Nutrient digestibility and protein quality (DIAAS)
- Custom requests
Experience our cutting-edge systems in action
Watch our systems replicate the human GI tract and discover the benefits of our innovative SurroGUT™ platform
Latest News
Latest news and developments from InnoGI Technologies
Contact us
For any questions and requests, you can reach out to us using the contact form, or send us an e-mail!
Thijsseweg 11
2629 JA Delft
The Netherlands