Case study
Alternative fungal supplements for pancreatic insufficiency
Efficacy of oral fungal lipase compared to traditional porcine lipase in lipid digestion under severe pancreatic insufficiency conditions simulated in the upper GI model tiny-TIM. Fungal enzymatic supplements, administered as capsules or powder, seem an alternative treatment for pancreatic insufficiency.
The approach
Efficacy of oral pH-stable fungal lipase compared to traditional pH-sensitive porcine lipase in lipid digestion and absorption, measured as total fatty acid bioaccessibility, under severe pancreatic insufficiency conditions simulated in the upper GI model tiny-TIM. Results with encapsulated fungal enzymes compared with the intake of the powder content to simulate administration in patients unable to swallow whole capsules
Services
TIM's
Industry
The results
- Significant improvement in total fatty acid bioaccessibility with three tested lipase supplements (Nortase 45.3%, Kreon 47.7%, and Pangrol 49.1%) compared to severe pancreatic insufficiency control (33.9%).
- Similar lipid digestion between fungal lipase Nortase (14.000 units) and porcine lipase Kreon and Pangrol (20.000 units).
- Powder content of Nortase capsule, as administered to patients unable to swallow, had no negative effect compared to whole capsule ingestion.
Fungal enzymatic supplements, administered as capsules or powder, result in comparable lipid digestion as porcine supplements.
How InnoGI helped
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