Mimicking the large intestine
TIM Colon
TIM Colon is a cutting-edge, dynamic, in vitro model of the large intestine, designed to replicate colon conditions with high precision. TIM Colon is typically used to evaluate and rank oral drugs and microbiome modulators (such as prebiotics) and to assess the impact of nutrition on microbiome composition & metabolism.
Why the microbiome matters
Our microbiome is essential for our health. Disruption of the gut microbiome has been associated with various (gastrointestinal) diseases, underscoring its significance in human health. Did you know your gut microbiome seriously interacts with foods and drugs? Hence, developing new oral products warrants the evaluation of their impact on and interaction with the gut microbiome.
Applications
Asses microbiota composition and activity
TIM Colon can be used to study the release, dissolution, and stability of drug formulations in the large intestine, as well as to assess the prebiotic potential of (novel) food products and ingredients by assessing their impact on the gut microbiome.
This service enables comprehensive investigation of drug–microbiota interactions and API bioaccessibility, and detailed insights into microbiological composition and metabolites such as SCFAs, TIM Colon helps you understand the true impact of your product on the gut microbiome!
TIM Colon enables ranking and selecting formulations in research and development and de-risking a clinical trial or product launch. Combine with TIM Upper GI to complete the full digestive profile!
Dynamic model with continues metabolite removal
Unique features
- Dynamic, computer-controlled in vitro model simulating the colon
- Maintaining healthy microbiota by removal of metabolites
- Anaerobic environment with controlled conditions (pH and temperature)
- Inoculated with highly dense and active microbiota
- Short adaptation period ensures highest physiological accuracy
- Sampling of both of dialysate and lumen
- Simultaneous assessment of both luminal and mucus associated microbiota
Get in contact
We are excited to hear what’s on your plate and how we can help you understand what happens to your product during digestion!
