Pharmacokinetics fed by TIM data
TIM PK
TIM PK is an in silico approach that translates accurate physiological TIM® drug release, dissolution and/or permeation data into predicted in vivo absorption and pharmacokinetics (PK). TIM PK is typically used to predict absorption, distribution, metabolism and excretion (ADME), guide (drug) formulation optimization and deliver in vitro–in vivo correlation (IVIVC).
Why pharmacokinetics matters
Pharmacokinetics focuses on how medications are absorbed and move through the body. Understanding how drugs are metabolized helps scientists understand how long a substance remains in the blood and which bodily functions are affected.
Selecting the right active pharmaceutical ingredient (API) and designing effective oral formulations is becoming increasingly challenging. Many APIs show poor solubility or unpredictable absorption, and conventional dissolution methods fall short in predicting human pharmacokinetics, creating costly inefficiencies and uncertainty in bringing new therapies to market.
Applications
Guide formulation optimization, clinical strategy and regulatory confidence
TIM PK can be used to predict absorption, distribution, metabolism, and excretion (ADME) processes, as well as pharmacokinetics (PK) for challenging APIs and complex oral formulations. It enables evaluation of food effects, virtual bio-equivalence, first-in-human dose prediction, and in vitro-in vivo correlation (IVIVC) with high accuracy.
TIM PK translates formulation behavior as determined in TIM Upper GI experiments (including e.g. food effects, atypical gastric emptying etc.) to expected performance in patients or populations. It also supports in building regulatory credibility by investigating bio-waiver potential and create confidence by evaluating drug performance at extreme conditions, helping developers build stronger submissions and make informed, evidence-bases decisions.
TIM PK helps you to get unmatched insights and actionable predictions, accelerating smarter, safer, and more effective drug development.
TIM PK translates formulation behavior assessed using TIM Upper GI to expected performance in a patient or population
Unique features
- Directly fed by TIM Upper GI, TIM Colon and/or TIM Cell derived in vitro data for the most reliable outcome
- Uisng industry-leading PBPK/PBBM software, trusted by regulators and applied across diverse real-world and regulatory use cases
- Able to predict drug performance at extreme conditions
- Identification of critical bioavailability limiting attributes
Get in contact
We are excited to hear what’s on your plate and how we can help you understand what happens to your product during digestion!
